Chloroquine retinopathy: is there a safe daily dose?

Chloroquine retinopathy: is there a safe daily dose?

Published case reports of chloroquine retinopathy rarely include details of daily dosage, but 30 reports where this information was available included 78 patients who developed impaired visual acuity an 13 had received daily doses of 250 mg or less. Eleven cases of ocular toxicity attributed to chloroquine were reported to the Committee on Safety of Medicines but only 2 developed impaired visio...

There Is No Safe Dose of Prions

Understanding the circumstances under which exposure to transmissible spongiform encephalopathies (TSEs) leads to infection is important for managing risks to public health. Based upon ideas in toxicology and radiology, it is plausible that exposure to harmful agents, including TSEs, is completely safe if the dose is low enough. However, the existence of a threshold, below which infection proba...

Hydrallazine in hypertension: is there a safe dose?

353 caesarean sections (incidence 25%). We do not think that the apparently high rate of surgical interference bears any relation to the use of intrathecal morphine, but it is too early yet to be sure. Our next eight patients (not reported here) all delivered spontaneously, thus reducing the incidence of both forceps delivery and caesarean section to 15 ". In 1979 the incidence of forceps deliv...

Chloroquine: consideration of maximum daily dose (3.5 mg/kg ideal body weight) prevents retinopathy.

[Chloroquine retinopathy].

Chloroquine Retinopathy refers to the changes seen in the retina of patients due to long term use of chloroquine. The late presentation, classically described as bull’s eye maculopathy, is preceded by a number of subtle changes. With the advent of new investigation modalities and regular screening, it is possible to prevent irreversible retinal damage due to this important and widely used drug....